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課程名稱 |
細胞微機電及微流體導論
Introduction to Cellular BioMEMS and Biomicrofluidics |
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開課學期 |
103-2 |
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授課對象 |
學程 奈米科技學程 |
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授課教師 |
許聿翔 |
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課號 |
AM7166 |
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課程識別碼 |
543EM5310 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期二6,7,8(13:20~16:20) |
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上課地點 |
應107 |
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備註 |
本課程以英語授課。
總人數上限：20人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1032AM7166_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
課程名稱: 細胞微機電及微流體導論
(Introduction to Cellular BioMEMS and Biomicrofluidics)
1. Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality.
2. Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis.
3. BioMEMS: Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing.
4. Microfluidics: scaling laws, surface to volume ratio, hydraulic resistance, wall shear stress, diffusion, capillary flow, hydrodynamics in porous media.
5. Special topic: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping.
6. Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration.
7. Special topic: Tissue microengineering - 3D culture, angiogenesis, vasculogenesis, organ on a chip. |
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課程目標 |
本課程目標為二:
(1) 介紹如何將基礎力學應用在細胞與組織之基礎生物力學分析，並從中解釋其主要機能及物理意義; (2)介紹如何將基礎力學應用在微機電系統及生物微流體流道設計，並應用於細胞力學之研究與醫學上的應用。 |
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課程要求 |
No |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
上課講義 |
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參考書目 |
Major textbook: Introduction to BioMEMS, Albert Folch, CRC Press; 1st ed.
(August 21, 2012)
Ch1 How do we make small things?
Ch2 Micropatterning of substrates and cells
Ch3 Microfluidics
Ch5 Cell-based chips for biotechnology
Ch6 BioMEMS for cell biology
Ch7 Tissue microengineering
Reference textbook：Essential Cell Biology, Bruce Albert, et al. Garland
Science, 2nd ed. (September 25, 2003)
Ch17 Cytoskeleton
Ch19 Cell division
Introductory Biomechanics - From Cells to Organisms,
C. Ross Ethier and Craig A. Simmons, Cambridge University Press
(April 9, 2007)
Ch2 Cellular biomechanics
Ch4 The circulatory system
Ch5 Interstitial fluid flow
Fundamental of Microfabrication, Marc Madou, CRC Press
Ch1 Lithography
Theoretical Microfluidics, HenrikBruus, Oxford University Press,
(Nov 17, 2007)
Ch3 Basic flow solutions
Ch4 Hydraulic resistance and compliance
Ch5 Diffusion |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Midterm |
30% |
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2. |
Preproject present |
20% |
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3. |
Project present |
20% |
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4. |
Project report |
30% |
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週次 |
日期 |
單元主題 |
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第1週 |
2/24 |
Introduction to Lab-on-a-Chip systems (Micro Total Analysis Systems) |
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第2週 |
3/03 |
Scaling Law |
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第3週 |
3/10 |
Photolithography |
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第4週 |
3/17 |
SU-8 Negative Photoresist |
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第5週 |
3/24 |
Substrate cleaning & Soft-lithography |
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第6週 |
3/31 |
Cellular Biomechanics |
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第7週 |
4/07 |
BioMEMS for Cell Biology |
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第8週 |
4/14 |
Tensegrity model |
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第9週 |
4/21 |
Bioreactors in Microfluidic Devices |
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第10週 |
4/28 |
Midterm |
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第11週 |
5/05 |
Endothelial cell, Angiogenesis, Vasculogenesis |
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第12週 |
5/12 |
Myocytes, Skeletal muscle, Cardiac myocyte |
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第13週 |
5/19 |
Neurons |
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第14週 |
5/26 |
Neurons & Organ on a chip |
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第15週 |
6/02 |
Organ on a chip & Cancer research |
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第16週 |
6/09 |
Molecular diagnostics |
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第17週 |
6/16 |
Student Pre-project report |
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